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Description
5-Amino-1MQ is a small molecule NNMT inhibitor investigated in preclinical models of nicotinamide metabolism and NAD+ salvage pathway signaling
When the studies were categorized according to the route of administration, a significant reduction in plasma Lp(a) concentration was observed with oral (WMD: 9.00mg/dL, 95% CI: 10.29, 7.72, p<0.001) but not intravenous L-carnitine (WMD: 2.91mg/dL, 95% CI: 10.22, 4.41, p=0.436)
This novel approach showed great potential in the treatment of ulcerative colitis
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