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ROS as double-edged swords in cancer Several noncancer cells associate with tumors: among these, cancer-associated fibroblasts (CAFs), particularly represented in the tumor microenvironment (TME), actively contribute to the regulation of tumor homeostasis, promoting tumor progression and the invasion of cancer cells

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Furthermore, activity of the BER pathway was significantly increased in sALS patients (Kisby et al., 1997

Proteasome inhibitor PS-341 inhibits NF-B activity and promotes tumor cell apoptosis in renal cell carcinoma cell lines[63]