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TRPA1 sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy

Bryan HK, Olayanju A, Goldring CE, Park BK

Previous metabolomics studies have reported LID-specific alterations of glycerophospholipids and endocannabinoid signalling in dyskinetic rodent models 20 and significant dysregulation in glycosphingolipid metabolism in plasma and cerebrospinal fluid (CSF) samples from LID patients, correlating closely with the severity of dyskinetic movements 21