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When O 2 is neutralized, H 2 O 2 is produced, which can be metabolized into non-toxic products by a catalase (H 2 O 2 + H 2 O 2 2H 2 O + O 2 ) and glutathione peroxidase (GPx) in conjunction with glutathione (2GSH + H 2 O 2 GSSG + 2H 2 O)

Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling