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10.1002/adfm.201902634 30 MauriE.SalvatiA.CataldoA.MozeticP.BasoliF.AbbruzzeseF.et al (2021)

These neurons, originating from cell bodies in the nucleus accumbens (NAc) and ventral tegmental area (VTA), communicate with the prefrontal cortex via functional connectivity.14,15 Opioids indirectly activate these neurons, inducing DA release, which provides rewarding and analgesic effects.16 DA-depleting lesions in the ventral midbrain, which contain cell bodies for ascending forebrain projections, block morphines analgesic effects, underscoring the role of mesolimbic DA neurons in pain suppression.17 The Role of DA in Pain Management Pain pathways primarily originate in the dorsal horn of the spinal cord and medulla, but additional neurological loci, particularly within the mesolimbic system (the brains reward center), play a crucial role in modulating pain sensitivity

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