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This would suggest that 3D cultures may be used to study MB behavior and drug sensitivity, mimicking better the in vivo physical conditions (113)

Figure 3 Additionally, the activation of NF-B leads to increased expression of key genes, including proinflammatory cytokines like IL-6, IL-8, IL-16, and TNF-, which contribute to inflammation

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Specifically, factors such as heterogeneity in the tumor microenvironment, variations in metabolic characteristics, gene expression and mutation status, immune system activity, and prior treatments and drug responsiveness may all regulate the efficiency of ferroptosis induction in tumor cells and the therapeutic effects