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JAMA Facial Plast Surg 20(3):196201
What is missing is human RCT data showing the combination outperforms either compound alone

The association of homocysteine, folate, vitamin B12, and vitamin B6 with fracture incidence in older adults: a systematic review and meta-analysis
Mood disorders such as depression and bipolar are very much associated with B12 deficiencies (7, 8)
