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2.Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB

The consequences of NNMT inhibition over months or years are unknown

Maintenance therapy is usually monthly

In a randomized multicentre study, liposome-encapsulated doxorubicin (LED) and doxorubicin (DOX) treatment in addition to surgery (but without radiation) led to a prolonged median disease-free interval when compared to surgery alone, with no difference in efcacy between LED and DOX (Poirier et al., 2002)
