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Animal studies using continuous administration over extended periods confirmed the safety profile

Inadequate response to therapy is serious since residual symptoms increase the risk of relapse and recurrence of MDD.3 Risk factors contributing to inadequate response are misdiagnosis, presence of depressive subtypes, and medical and psychiatric comorbidities

Animal studies show protection against myocardial infarction damage, arrhythmia prevention, and a unique ability to activate collateral blood vessel pathways