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Contacts and hydrogen bond persistency are quantified as the percentage of frames (over all the frames obtained by merging the different replicas) in which protein residues formed contacts or hydrogen bonds with the ligand

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In addition, icaritin upregulates CXC chemokines (e.g., CXCL9 and CXCL10) and T cell marker factors (e.g., CD8 and IFN- ), facilitating the recruitment of immune cells to tumors, and formed a "hot" tumor microenvironment in lung cancer (Lewis) cells [713]