glutathione conjugation metabolism of to a generic xenobiotic (X) via catalysis by Oxidative metabolism and glutathione conjugation

Antioxidants (Basel, Switzerland), 2021, 10(12):1864

Furthermore, Nrf2/HO-1 interacts with the NF-KB and JAK-STAT pathways in various contexts: Nrf2/HO-1 can reduce NF-KB phosphorylation and thereby dampen inflammation, whereas proinflammatory cytokines such as TNF- and IL-6, released following NF-KB activation, upregulate HO-1 in a feedback loop (125, 129)

It has been hypothesized that a smaller number of cytosolic GST genes in the European honey bee ( Aphis mellifera ) than in other insect species might be associated with pesticide sensitivity and reduction in vitality [72]

Ureases: Historical aspects, catalytic, and non-catalytic propertiesA review