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Glutaredoxin (Grx), a GSH-dependent disulfide oxidoreductase, catalyzes dithiol reactions, reducing GSH-protein mixed disulfides in a coupled system with GR and NADPH as an electron donor (58, 72)

Epidemiological data indicated that approximately 20% of patients with AP developed severe AP, which was characterized by dysregulated cytokine storms that exacerbate pancreatic damage and precipitate multi-organ failure (e.g., pulmonary insufficiency, intestinal barrier dysfunction) (Iannuzzi et al., 2022), which undoubtedly imposed substantial socioeconomic burdens on patients, families, and healthcare systems

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