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Also, no specific time-course has been observed between disease presentation and development of cardiomyopathy, with nearly 50% of cases affecting patients with early onset and nearly 50% with late onset, and mean age at diagnosis of 6.5 years, ranging from 3 weeks to 25 years

also conducted a randomized observational double-blind placebo-controlled trial (N = 92 LOE2a) which showed that LC reduced the incidence and severity of degenerative diseases in elderly patients

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