glutathione treat cancer 1888 Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Glutathione-Dependent Pathways in Cancer Cells

Consequences of oxidative stress Oxidative attack by ROS is manifested as damage to nucleic acid bases, lipids and proteins, which can severely compromise cell health and viability or induce a variety of cellular responses through the generation of secondary reactive species, ultimately leading to cell death by necrosis or apoptosis [48]

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Translational pathways should also focus on integrating GST polymorphism data into polygenic risk scores, pharmacogenomics, and multi-omics frameworks

Gastrointestinal effects such as nausea, vomiting, and diarrhea may arise, particularly at the start of treatment or after a dose increase