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marneffei is in agreement with the diversification of Gst proteins found in fungi and other organisms 33

Up-regulation of GSK-3 activity leads to phosphorylation of the amyloid precursor protein (APP) and the protein tau, both of which are associated with the pathological processes that lead to the hallmarks of Alzheimer's disease (AD), amyloid- plaques and neurofibrillary tangles (Hanger and Noble, 2011

JKIMSU 2013;2:69-76

By lowering the mRNA expression of inflammatory cytokines such as TNF-, IFN-, IL-1, and IL-6, reducing macrophage infiltration, and preventing inflammatory signal transduction, GLPs effectively mitigate chronic inflammation