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Elevated N-glycosylated cathepsin L impairs oocyte function and contributes to oocyte senescence during reproductive aging

Major focus will be placed on Complex I of the respiratory chain since (1) it is a target for reversible S-glutathionylation by Grx2 and (2) deregulation of Complex I S-glutathionylation is associated with development of various disease states particularly heart disease

doi: 10.1038/s41423-020-00630-3

Josefs T, Barrett TJ, Brown EJ, Quezada A, Wu X, Voisin M, et al
