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Using 18F-fluorodeoxyglucose positron emission tomography, researchers have detected significantly elevated glucose metabolism in human atherosclerotic plaques, particularly within lipid-rich necrotic cores and regions densely infiltrated by immune cell (106, 107), high-risk plaques, in particular, display increased glycolytic activity (108), and as a metabolic hallmark of trained immunity (109, 110)

Mitochondrial dysfunction can also occur as a consequence of both acute and chronic IOP elevation

[DOI] [PMC free article] [PubMed] [Google Scholar] Eggleston W, Stoppacher R, Suen K, Marraffa JM, Nelson LS (2019) Kratom use and toxicities in the United States

Although all the proteins of the PDHc have been found to be localized to the nucleus, the major protein of the PDHc that has been shown to be transported into the nucleus is the subunit of the E1 portion of the complex which is encoded by the PDHA1 gene