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In healthy mitochondria, SIRT3 interacts with ATP5O, while the low pH owing to the loss of membrane potential weakens the binding affinity between SIRT3 and ATP5O, leading to the redistribution of SIRT3 to other mitochondria substrates

Asian J Psychiatr 55: ARTN102532

Steroids, because they affect so many tissue types, generate a far wider and less predictable side effect profile

Male pseudohermahroditism due to 5 alpha-reductase-deficiency
