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46 Confirmed Safety of Deutetrabenazine for Tardive Dyskinesia in a 2-Year Open-label Extension Study CNS Spectrums [10928529]
(2016) suggested that AO activates Akt, directly induces phosphorylation of Drp1 at Ser616, promotes mitochondrial fragmentation, and triggers downstream events such as the release of reactive oxygen species (ROS)
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Further, diminished growth factor signaling under these conditions significantly attenuates cellular proliferation (154)
