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4.4 Cysteine and homocysteine in neurological disorders Homocysteine is transported into the brain, and the brain has a limited capacity for Hcy metabolism

Enhanced mTORC1 activation, a hallmark of IECs lacking Stard7 and showing or not constitutive Wnt signaling, is ROS-dependent as NAC interferes with mTORC1 activation and consequently with the Atf4-dependent transcriptional reprogramming

FASEB J 34:1046210475 Wang S, Lv D, Jiang S, Jiang J, Liang M, Hou F, Chen Y (2019) Quantitative reduction in short-chain fatty acids, especially butyrate, contributes to the progression of chronic kidney disease