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In order to expand the toolbox of protocols for one-pot PROTAC synthesis using building blocks with different functional groups, Krumbs group published a new library of cereblon-based PROTACs targeting BRD4 protein via amide formation after a one-pot synthesis photoinduced C(sp 2 )C(sp 3 ) coupling (yields ranging from 7 to 93%)

BPC 157 offers a sophisticated approach to promoting cellular recovery for soft tissue and gastrointestinal health

10.1111/j.1600-0854.2010.01145.x
