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Melanocortin agonists include PT-141 and Melanotan II, while mitochondrial and longevity peptides include MOTS-C and Epithalon

This highlights the roles of inflammation, oxidative stress, and leptin and insulin resistance in disrupting the hypothalamic-pituitary-testicular axis in men with metabolic disease

Tirzepatide occupies the middle ground: broader than classical GLP-1 analogues, but more selective than triple agonists
