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ERK5 is a two-kinase transcription factor, and phosphorylation of ERK5 S496 directly inhibits NRF2 protein activity through SUMOylation modification at site 518, an inhibitory effect that can lead to inflammation and mitochondrial dysfunction in macrophages [133]

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

Patients diagnosed at an older age are more likely to have high-grade malignancies, whereas younger patients are more likely to have lower-grade, lower-stage, non-muscle invasive disease [10, 11]