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The inhibition of mitochondrial bioenergetic function by hyperoxia results in mitochondrial dysfunction, evidenced by a reduced membrane potential (Audi et al

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The methods used to increase the intracellular levels of glutathione that have shown efficacy are the administration of compounds that favor cysteine availability [45]

In fact, strategies aimed at buffering microenvironment pH before administration of standard chemotherapy have been proposed by both preclinical 42 and clinical studies [Clinical trials NCT01198821] 43