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If you are extremely sensitive and find that taking the supplement on a completely empty stomach causes mild nausea, clinical evidence suggests pairing it with a very small, light snack (such as a few bites of fruit or a cracker) can mitigate digestive discomfort while still preserving the stability of the acetylated molecule

Ingerman, E

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Consistent with what the authors observed in the human CNS, both EAE mice and CPZ mice showed intense upregulation of ATP7A, ATP7B, and CTR1 on astrocytes in the spinal cords in comparison to control mice (Colombo et al., 2021)