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Ethics statement The requirement of ethical approval was waived by the University of Wisconsin Madison Institutional Review Board for the studies involving humans because this is a retrospective chart review project

Sample preparation and liquid chromatography-mass spectrometry analysis A 100-L aliquot of plasma was mixed with 400 L of ice-cold chloroform-methanol (2:1, v/v) containing stable isotope-labeled internal standard L-carnitine-d3

Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mos

For high thyroid hormone levels (hyperthyroidism): 2-4 grams of L-carnitine has been taken daily for 2-4 months