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USA 113 , 206211 (2016)

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Mechanistic investigations clarify this selective recovery signaling: Selective somatotroph targeting reduces activation of ACTH-secreting corticotroph cells In vitro pituitary assays show preserved GH release with negligible prolactin secretion Comparative endocrine panels confirm minimal cortisol elevation relative to hexarelin or GHRP-6 Moreover, receptor-binding analyses [3] indicate that ipamorelin demonstrates high affinity for GHSR-1a without broad engagement of alternative pituitary receptor systems

After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency
