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they recruit cAMP response element-binding protein (CREB)-binding protein (CBP) or receptor-associated coactivator 3 (RAC3), to facilitate the transactivation of NRF2 target genes [146, 147]

24,25 The role of neutrophils is also relevant

Niacinamide 5-10%: Inhibits the transfer of melanin from melanocytes to keratinocytes, which is the mechanism by which pigment moves into the visible skin layers
