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Notably, inhibition of this pathway has been found to alleviate synapse loss and neurodegeneration in murine models of AD (Wu et al., 2019

Outcomes measures Primary PK endpoints were the area under the serum concentration-time curve from time 0 to the last measurable concentration time point after drug administration (AUC 0-t ) and the maximum serum concentration (C max )

10.1111/bjh.16446 140 ParkS

Teunissen, C