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The ITM2B gene interacts directly with APP at the cell membrane and inhibits its cleavage by - and -secretases, thereby preventing the generation of -amyloid peptides (A), which are known for their neurotoxicity and their role in the formation of senile plaques characteristic of Alzheimers disease (53)

56 Inhibitors of bromodomain-containing protein 4 A comparative transcriptome analysis of mouse MPNSTs and their cells of origin revealed that the gene encoding bromodomain-containing protein 4 (Brd4) is one of the most highly upregulated genes in MPNSTs

Takahashi and Mashima, 2022

Trained immunity in organ transplantation