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Heavy continual cigarette smoke is alleged to contain a variety of harmful constituents, such as cadmium [184,185]
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In addition, a lower intake of vitamin B12 seemed to be associated with a delayed sleepwake rhythm [28] and a higher prevalence of insomnia symptoms, assessed by the Insomnia Screening Questionnaire [36]
Paracrine signaling can induce senescence in adjacent healthy cells, a phenomenon known as the bystander effect
