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Description
Acetylated Histones in Apoptotic Microparticles Drive the Formation of Neutrophil Extracellular Traps in Active Lupus Nephritis
Epigenetic regulation of gene expression occurs through a multitiered mechanism without altering DNA sequences [9]
Secondly, ROS has a dose dependent effect on activity of proteins leading to differential downstream outcomes [140], which are distinct in the setting of exogenous and endogenous ROS, and need to be evaluated in phase 1 dose finding studies with appropriate pharmacodynamic/ pharmacokinetic readouts
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