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Targeting this mechanism, stem cells, particularly mesenchymal stem cells (MSCs), can exert protective effects by mitigating cellular oxidative damage and aberrant mitochondrial function

Improved skin elasticity, skin moisture, joint flexibility and hair health illustrate the beneficial effects of Pycnogenol on the extracellular matrix, observed in RDP studies (4044)
[1] Evidence accumulated over four decades indicates that topical tretinoin accelerates epidermal turnover, refines follicular architecture, and stimulates dermal collagen remodeling, while azelaic acid provides comedolytic, antimicrobial, and tyrosinase-inhibiting activity

Among those candidates, we selected four enzyme complexes comprising eleven identified targets for further experimental validation based on the availability of suitable inhibitors
