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10.1001/jamapediatrics.2015.2125 201 MezianeH.SchallerF.BauerS.VillardC.MatarazzoV.RietF.et al

As the field develops, direct measurement of circulating MOTS-c may become a useful biomarker for guiding dose adjustments, similar to how IGF-1 is used to monitor growth hormone or testosterone levels guide TRT dosing

HPLC-UV validation is standard

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