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Similar to typical EDCs [10], iodine does not have a precisely defined threshold dose above which it is definitely dangerous and below which it is absolutely safe in all exposed individuals

Marine collagen, derived from fish skin and scales, generally shows excellent safety profiles and high bioavailability

These signaling events are believed to contribute to their nephroprotective effects [ 90 ]

In addition, Anraku et al (59), using in vitro experiments, found that HNA1 affects the binding ability of Sites I and II [two specific drug binding sites, located in subdomains IIA and IIIA, respectively (69)], with a greater effect on Site II (23,59) (Fig