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The GLP-1R, present in glutamatergic neurons in hypothalamic nuclei such as the arcuate nucleus and the paraventricular nucleus (PVN), contributes to the increased hepatic FGF21 most likely via direct autonomic nervous system circuits from the brain to the liver

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the active ingredients can be administered by the intravenous route in liquid dosage forms, such as solutions, suspensions, or emulsions