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Emerging evidence shows that a variety of genetic factors delicately regulate MSC self-renewal and differentiation

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Initial results from early randomized placebo-controlled studies such as the Women's Health Initiative suggesting that HRT increased the risk of coronary heart disease and breast cancer across the board in postmenopausal women were inappropriately interpreted and communicated with the public, leading to sharp declines in HRT prescriptions (115, 116)

The reduction of immunosuppressive cells will ultimately improve the efficacy of tumor immunotherapy