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The most important of these are polymorphisms in the promoter of the INS (insulin) gene, which modulate intrathymic insulin expression and can impair the elimination of insulin-responsive T cells during central tolerance

10.1074/jbc.R111.285742 101 HisadomeM.FukudaT.TerasawaM

Since discontinuing vitamin B12 supplementation for such a long time may have an adverse effect on the clinical condition of the patient, shorter, effective schemes of desensitization with this vitamin are sought

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