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Genomic aging, clonal hematopoiesis, and cardiovascular disease

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What Happens in Intervertebral Disc Degeneration Intervertebral disc degeneration is characterized by progressive structural and biochemical changes, including: Loss of proteoglycan content Reduced water retention (disc desiccation) Decreased disc height Altered mechanical properties Increased susceptibility to herniation and annular fissures These changes disrupt spinal biomechanics and may contribute to pain, nerve compression, and reduced mobility