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Through the activation of cyclooxygenases, phospholipase A, and arachidonic acid, metabolites are produced which include leukotrienes, platelet-activating factors and prostaglandins (Jimenez-Rodriguez et al

For this reason, a novel graft engineering approach was adopted by the group of Stanford, where nTregs and conventional T cells were formulated in defined ratios and administered in a temporally predefined sequence

Levine ME, Lu AT, Quach A, et al
The timing principle applies across the stack
