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10.1038/nature01137 Nature

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Mice null for ALDH1A1 and ALDH2 exhibit Parkinson's disease-like age-dependent deficits in motor performance and significant increase in biogenic aldehydes

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Key toxicities to watch: Myelosuppression infections, bleeding risk Mucositis & diarrhea GI toxicity Hand-Foot Syndrome skin redness, pain, peeling (esp

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This directly affects the extent of the drugs retention time in the blood

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