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Although prion diseases primarily affect the central nervous system, causing neurodegenerative conditions, prions can also spread to other tissues, such as lymphoid organs, sometimes resulting in systemic involvement

Severe renal impairment-especially anuria (inability to produce urine)-is a primary contraindication

They demonstrated that quercetin 3-O- -D-glucuronide (Q-3-G) decreases ROS through NF-B pathway, exhibiting significant anti-inflammatory and antioxidant properties, with promising therapeutic potential for radiation-induced skin inflammation 33

However, issues such as drug resistance and associated side effects have significantly restricted the clinical application of these treatments