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Grothey A, Nikcevich DA, Sloan JA, Kugler JW, Silberstein PT, Dentchev T, et al

Also, The National Institutes of Health and the Institute of Medicine have determined that no adverse effects have been established from excess amounts of B-12 in the body

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like skin rash, hives with itching and red swollen blistered peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, trouble swallowing, trouble talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat

A coffee enema is a type of colon cleanse in alternative medicine