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Nevertheless, it is not an impervious barrier, but rather selectively regulates what passes through the paracellular space

[DOI] [PubMed] [Google Scholar] 142.Sun Z, Feng J, He M, et al

Early studies suggested an interaction of A-related pathways with UA: Peroxynitrite scavenging UA prevents A-induced damage by inhibiting tyrosine nitration of synaptophysin (a membrane protein involved in learning and memory) [220]

These signals, in turn, can modulate calcium channels on the endoplasmic reticulum (ER), and prolonged dysregulation of this feedback loop increasingly contributes to calcium signaling abnormalities resembling those observed in the AD phenotype (Gibson et al., 2012)