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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (355) to translocate into the brain and promote inflammation ( Figure 10 )

When used under dermatological supervision, it can significantly reduce the appearance of freckles

Tobacco smoke is a significant risk factor for COPD and at least 25% of smokers develop this disease [2]

Floh et al, 1997
