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This observation is consistent with the DRB1*15:01 allele belonging to one of the three oldest ancestral haplotypes (DR2-DQ6, DR3-DQ2, and DR4-DQ8), which have survived over time due to their ability to recognize a greater diversity of antigens, allowing them to detect and eliminate a greater number of pathogens (113, 114)

Recent UTI was determined from the RICE screening questionnaire which asks whether the subject had a UTI or antibiotic treatment for UTI within the past three months

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Metabolite treatment in cells 293T cells were plated in 6-cm dishes and cultured in Dulbecco Modified Eagles Medium (DMEM) containing 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin (PS)