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MYCN amplification, CASP8 hypermethylation, and amplification of chromosome 17q, which encodes, amongst others, the anti-apoptotic protein Survivin, are some examples of common NB aberrations that contribute to apoptosis resistance 1,4,5
Moreover, results from animal studies have consistently demonstrated the detrimental effects of oxidative stress on central nervous system 15,16
10.1038/ncb1724 63 KciukM.KoatD.Kauziska-Koat.GawrysiakM.DrozdaR.CelikI.et al (2023)
Boullosa, L
