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doi: 10.1016/j.diabres.2022.109775
In contrast, other CNS-expressed isoforms, including PDE2, PDE4, PDE8, and PDE9, exhibit broader distribution profiles, regulate global rather than microdomain-restricted cyclic nucleotide signaling, and provide limited evidence for disease-specific relevance in schizophrenia
Risk of dementia associated with atrial cardiopathy: the ARIC study
While AOD-9604 works systemically once absorbed, injecting near the target fat depot provides the highest local concentration during the brief peak activity window
