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10.1074/mcp.M900325-MCP200 38 FrovaC
Jefferson Imaging Symposium
American College of Surgeons Clinical Congress 2022, 2022
In ovaries, it seems that CSE must be silenced upon malignant transformation, since it is expressed in normal epithelial ovarian cells but it is absent in malignant tumors ( 2 S production, which activates cancer cells proliferation and migration, through ROS/PI3K/AKT/mTOR and MAPK pathways ( Cysteine degradation catalyzed by CAT and MST (Figure 1B) is not deeply explored in cancer, since MST is more enzymatically efficient at a pH higher than the physiological, thus the role of CBS and CSE is considered more relevant in cancer biology ( 2 S from N-acetylcysteine instead of cysteine-derived 3-mercaptopyruvate
