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When superposing a predicted model of full-length CTL1 on our experimentally determined CTL1 model, the prediction helps to approximate where unmodeled regions of the extracellular domain and M3/M4 protrude from the micelle, matching the map when displayed at a lower contour level (Fig 4C)

They observed that etomoxir administration resulted in an increase in the mortality of aged but not adult ALI mice, thereby confirming that the CPT system is essential for survival from severe lung injury and indicating that adult mice have improved resilience to FAO inhibition